Acromegaly Essay Example for Free

Acromegaly Essay I. Introduction The human body contains various structures and organs that allow regulations and maintenance of homeostasis. Foundation is built through the framework of the skeletal system, motion is possible due to the muscular system humans have and other body systems that allow humans to perform daily actions. All of this anatomical structures are possible due to the two main controlling system found in the body; the nervous system and endocrine system. The nervous system can be considered as information processor of the human body, but for it to be more effective in transferring and processing information; it works in tandem with the endocrine system. The purpose of the endocrine system is to act in response to the information the nervous system has processed. The endocrine system is made up of glands that secrete hormones, chemicals that are secreted to the bloodstream to be spread in specific target organs in the body. Seven major glands are found in the body, in which each gland works to ensure that the body develops properly and be regulated to maintain homeostasis. However, certain conditions are inevitable in the human body and anything bad or harmful to the endocrine system can affect a human’s development and growth. II. Endocrine Disorder  The Disorder Each person is unique and grows differently from each other. Various aspects can be considered when considering diversity. These aspects can be factors of the development of the human body itself. Some may be hereditary, inborn and some can be a result of exposure to unhealthy surrounding. A person grows, but there are cases where growing exceeds the normal rate and reaches to extreme compare to other people. This occurrence is called acromegaly, in which the secretion of growth hormone (GH) in the pituitary gland exceeds its normal production even after the growth plates in the body has closed already. Thus, making structures and bones that are still responsive to growth hormone particularly in the hands, feet and face to overgrow (Marieb, 2010). Acquiring the Disorder Acromegaly is a disorder of hyper secretion of growth hormone, in which the chances of getting it is very rare and can vary through the development of the human body. This condition is due to abnormal production of growth hormone that functions to determine body size, affecting tissues in the body. From muscle growth, short, facial bones to the long bones of the body, growth hormone acts as a metabolic hormone that affects human size and shape in an extensive period of time. It is very comparable to a person with gigantism disorder, only difference is that in acromegaly there is a continuous growth of different structures in the body even though the growth plates have closes. The chance of getting this disorder is low, estimated 40 to 60 out of a million people yet it is hard to identify early on (Abbassioun, 2006). One person can develop and acquire the disorder and not be able to notice it right away. Gender and Age Preference of the Disorder The fact that acromegaly is a disorder in the endocrine system, there is an equal chance of male and female acquiring it, unlike if it was a disorder in the reproductive system. Both sex has a percentage of 55 to 59 patients in a million on acquiring the disease (Parkinson, 2003). It seems very few but many of the people that have the disorder tend to disregard or notice it. There is a possibility that the disorder will take years before a patient will notice the major changes of appearance in the body. Even though some may notice it, there are high chances that the person that has it will not look for medical help for treating the disorder. In terms of age bracket, in children when there is an overgrowth it is often termed as gigantism. However, when it exceeds beyond the child age limit, on adults to be exact, it is highly considered as acromegaly. Geographical Preference of the Disorder Acromegaly is a rare disorder in the endocrine system with certain treatments and therapy to reduce the chances of the disorder from getting worse. Worldwide, acromegaly is equally distributed, however, the number of cases left untreated is often found in many developing countries. With the inability to pay for treatments and therapy and the lack of professional skill, most cases of acromegaly in developing countries are not cured. Fatality of the Disorder The increase of size and mass of bones, muscles and many tissues in the body as a result of acromegaly tends to disrupt the normal functions of many organs. For instance, the enlargement of the bones can overgrow faster than tissues and structures around it. In some cases, it can cause cardiovascular disease and respiratory disease due to the enlargement of bones and muscles that inhibits both cardiovascular and respiratory system to function normally. Bones can also get brittle and fragile and even result in more chronic disease such as osteoporosis. Treatment of the Disorder There are numerous treatments on the condition of acromegaly. Certain therapies and treatments worldwide are known to be effective. Out of a hundred patients with acromegaly, 60 of those patients can be cured through surgery (Stewart, 2000). In particular, the reductions of growth hormone levels are the most effective treatment known today for cases of acromegaly. If things comes to worse, the removal of a tumor in the anterior pituitary is the most practical thing to do to take out excessive amount of growth hormone. However, treatment of acromegaly cannot change back what the disorder have already done to the human body such as bone deformities (Bolanowski, 2006). III. Topic Hormone  Growth hormone or somatotropin is the hormone involved in the disorder of acromegaly. Produced by somatotrophs in the anterior pituitary gland, it functions as a metabolic hormone and determinant of body size. Growth hormones functions mainly on growth effects but it also has other aiding purpose in different parts of the body such as mobilization of fats, blood level increase, glycogen breakdown and more. The chemical nature of this hormone is protein based, hence the name somatotropin. It is originally made in the hypothalamus where it is secreted, then passes through the anterior pituitary gland before it enters the bloodstream. It is regulated through negative feedback, inhibiting the release of growth hormones when the amount in the bloodstream is high already. In terms of target tissues, it is very general, pretty much all the bone structure and most of the muscular system is affected by the growth hormone. It also has a very short half-life, ranging from twenty to thirty minutes. Typically, growth hormones are secreted the most during sleep; however, it decreases with age. Growth hormones cannot be naturally conjugated due to its own ability to inhibit its release when it is too much in the body already. IV. Mechanism of Action  Normal Effect of Growth Hormone The release of growth hormone in the body is due to two hormones that has antagonistic effects found in the hypothalamus. Growth hormone-releasing hormone or GHRH activates growth hormone release when it is needed to synthesize protein and does its growth promoting functions in the body. Inhibition of its secretion is due to the release of growth hormone-inhibiting hormone or GHIH (Marieb, 2010). GHIH is triggered by increase on levels of growth hormone in the bloodstream. There are two ways growth hormone can be classified in terms of when it is activated. First is indirect action, where it functions as a growth promoter. Second is direct actions such as metabolism and anti- insulin. Effect of Growth Hormone to Person with Acromegaly Hypersecretion of growth hormone is the major cause of acromegaly, Over secretion of growth hormone in children can be considered as gigantism, however, in adults, which age bracket shouldn’t grow bigger than before, an occurrence of over secretion of growth hormone is considered acromegaly. With gigantism body grows at a proportion, to say the least. In the disorder of acromegaly, a body part grows while certain structures everywhere else in the body doesn’t, which result in oversized parts of the body such as the hand or face. The main receptors of growth hormone on its indirect actions are skeletal and muscular.

Post WW II and Japan Essays -- essays research papers fc

  Ã‚  Ã‚  Ã‚  Ã‚  World War II took place beginning at 1939 and ending in 1945. Japan was the last opposing country to surrender to the US Allies on September 2nd, 1945. Ending the long, horrific seven-year war.   Ã‚  Ã‚  Ã‚  Ã‚  Upon Japan’s admitted defeat, the U.S. invaded and took occupation of the country for seven years. Though assumed to be a distressing circumstance and expected total domination, it was a benefit to Japan, for the United States to take control of them, rather than being a disadvantage. The occupation helped the recovery and development of Japan’s economy and also clarified understanding between the two countries.   Ã‚  Ã‚  Ã‚  Ã‚  When the United States took control of Japan during late summer of 1945, it proved to be a milestone for the entire world. Never before had one advanced nation attempted to reform the supposed faults of another advanced nation from within (Reischauer 221).   Ã‚  Ã‚  Ã‚  Ã‚  Both countries were uneasy, complaining the regarded issue at first. For the Americans, the very notion of democratizing Japan represented a stunning revision of the propaganda they had imbibed during the war. When the media had routinely depicted all Japanese as children, savages, sadists, madmen, or robots. In the most pervasive metaphor of dehumanization, they were portrayed in word and picture as apes, or â€Å"monkey-men† (Dower 213). There was much hatred for the Japanese by the American people, because of the negative depiction of them by the media and the remembrance of the bombing of Pearl Harbor by the Japanese that drove the U.S. to declare war on Japan in the first place. Many Americans displayed extreme prejudice for the Japanese people calling them â€Å"jaundiced baboons† or the more unsophisticated racial term, â€Å"Jap.† The United States viewed Japan as a collapsing nation that needed strict guidance from them in order to ch ange into the correct form of government.   Ã‚  Ã‚  Ã‚  Ã‚  For the first time in history, Japan was a conquered nation. The slogan, which Japan used to cope during the occupation, was â€Å"enduring the unendurable.† For some Japanese people, the U.S. occupation seemed like more of the same totalitarian leadership as of the emperor, therefore was indifferent to the new order. The rest feared that the Americans would be vengeful, cruel conquerors. The wil... ...tates and Japan is certainly an impressive achievement. Due to the aid and influences contributed by the United States, Japan is now a peaceful, fully restored nation that has improved beyond expectations. The economy is one of the best in the world, and there is no longer any hostility between the two nations. America helped Japan restore its economy and society to build it into a better nation that it is today. Bibliography Perez, Louis G. The History of Japan. London: Greenwood Press, 1998. Reischauer, Edwin O. JAPAN, The Story of a Nation. New York: Alfred A. Knopf, 1970. Morton, W.Scott. JAPAN, Its History and Culture. New York: McGraw-Hill, 1994. Area Handbook Series. Japan, a country study. Washington D.C.: Library of Congress, 1992. Beasley, W.G. The Modern History of JAPAN. New York: Frederick A. Praeger, 1963. Koshiro, Yukiko. Trans-Pacific Racisms and the US Occupation of Japan. New York: Columbia University Press, 1999. Beasley, W.G. The Rise of Modern Japan. New York: St. Martin’s Press, 1995. Thomas, J.E. Modern Japan. London: Longman Singapore Publishers Pte., 1996. Dower, John W. Embracing Defeat, Japan in the Wake of World War II. New York: Norton, 1999.

Questions concerning criminal law Essay

i. What are the specific aims & purposes of the criminal law? To what extent does the criminal law control behaviour? Do you believe that the law is too restrictive or not restrictive enough? The specific aims and purposes of criminal law is to punish criminals, and prevent people from becoming future criminals by using deterrence. â€Å"Having a criminal justice system that imposes liability and punishment for violations deter.† (Paul H. Robinson, John M. Darley, Does Criminal Law Deter? A Behavioural Science Investigation, Oxford Journal of Legal studies, volume 24, No. 2 (2004), pp. 173-205). Criminal law intimidates citizens because most people won’t want to be arrested or have a write up on their personal record. Criminal law controls behaviour but only outlines what a good citizen should be doing, by creating laws. â€Å"More precisely, the term refers to substantive criminal law – a body of law that prohibits certain kinds of conduct and imposes sanctions for unlawful behaviour.† (The Canadian Encyclopedia, Criminal Law, http://www.thecanadianencyclopedia.com/articles/criminal-law, para. 1.) Having laws and not enforcing them is pointless, so by creating a law you need to enforce it strictly so people stop committing the offence. Like in Alberta and other parts of Canada the Distracted Driving law was in full effect and anyone caught texting and driving or anything along those lines was given a major demerit dock, and a hefty ticket you need to pay. By doing this it enforces the law and creates that thought in the back of the citizens head that says â€Å"should I do that? What will happen if I text and drive and get caught?†. However, most criminals don’t have that subconscious thought and don’t care if they get caught breaking the law, that’s why so many criminals are re-offenders. Laws are either questions concerning criminal justice and safety too restrictive or not restrictive enough depending on where you live. Some people can be considered criminals in Canada, but be doing family honour killings in their homeland. Having pretty much non existent drinking ages in  Europe to the United States where you have to be 21 is absolutely unreasonable, and depending on where you live your laws can either be too restrictive, like in the US, or not restrictive at all, in Europe. There should be a universal drinking age of 16, and the driving age should be raised. Allowing teenagers and young adults to drive before they learn the effects of drinking is not a good policy. Too many citizens think because they have been driving for 2 – 4 years think that they can drive drunk which is not the case and creates a big problem. Among 18 – 24 year olds, they have the highest percentage in Canada for driving under the influence per 100,000 licensed patrons. Universally, if you lowered the drinking age and heightened the driving age to 21, hopefully less people would be drinking and driving because more people would have experienced the effect of alcohol before driving. If this actually worked then maybe less and less police officers would need to worry about check stops and be less restrictive on certain laws and would be able to focus on other important things around Canada. questions concerning criminal justice and safety  ii. Assuming that males are more violent than females; does that mean that crime has a biological rather than a social basis (because males & females share a similar environment)?  Statistically males made up for more then five times the amount of crime then females did in 2005. (Women and The Criminal Justice System, http://www.statcan.gc.ca/pub/89-503-x/2010001/article/11416-eng.htm.) Males aren’t biologically programmed to be more physically aggressive and commit more crimes, but when people say males commit more crimes because of testosterone, that is crazy because women have testosterone in their body’s too. Males commit more crimes because most males want to assert their â€Å"macho – ness† to females and prove that they are manly. When males are 20-25 years old, the highest category for committing a crime, they have no other ways to show females how manly they are other then fighting and committing crimes. I think the reason why older males don’t commit more crimes compared to the younger generation is because older folk have other ways to show their manliness like their job, how much money they have, or the kind of car that they drive. That being said crime has nothing to do with biology, but it  comes down to men trying to show how powerful they are in an attempt to â€Å"woo† a female. Concerning the fact that males and females sharing the same environment but males being â€Å"more violent†, I think the reason is because males aren’t as protected as females are. During high school kids always hear about fathers or brothers who will protect their child or sibling from anyone that hurts them in any way. You never hear a sister or a mother saying that about their questions concerning criminal justice and safety son. (Introduction to Criminology, Lecture 3, September 23, 2013, Professor Jan Stanners.) So another factor about females being less aggressive is the fact that they are protected more and almost restricted from certain things because more people worry about girls then boys. Studies are also showing that women’s crime rates are increasing quite noticeably while males are slowly dropping. I think this is because since the 1950-80’s women’s roles were typically stay at home moms taking care of the children, etc. But now women have a lot more freedoms and have jobs and can they can now do whatever they please just like males, so I think that’s why female crime rates are rising steadily. Also, according to the statscan government website it shows that females have a higher victimization rate between the ages of 18-44, which we expect because men are â€Å"more violent†. However after that age range the males become the more victimized group which I found very interesting because that in itself refutes any debate of men being more violent because of testosterone, because no matter how old you are your body is still producing testosterone. questions concerning criminal justice and safety iii. Do you agree with the assessment that for young people, a school is one of the most dangerous locations in a community? Did you find your high school to be a dangerous environment?  Ã¢â‚¬Å"According to the Bureau of Justice Statistics, 17 teens were killed at schools and five children killed themselves in the year ending June 30, 2002.† (School Safety, http://www.ncpc.org/topics/school-safety.) School can be a very dangerous place for teenagers depending on the area of town that they live in. In Calgary high schools are more safe down south then in  Forrest Lawn just because of the type of families and people there are around influencing the teenagers. The type of influence a teenager gets can lead them on the path to becoming a bully. At the Columbine shootings two teenagers shot and killed many innocent teenagers, in Michael Moores documentary it is shown that the two students were bullied occasionally which may have caused them to act out and shoot their peers. (Michael Moore, Bowling For Columbine, 2002.) As far as schools being one of the most dangerous areas in the community I find that hard to believe. Around schools you have teachers and counsellors supervising you and helping you throughout your 3 years so it can’t be as dangerous as people make it out to be. However the activities that take place outside of school I think are the most violent ones. They involve students and peers that you’ve met through high school and I believe people are getting those two things mixed up, but that’s just from personal experience because inside of my high school was relatively safe. We had a lockdown where a student from another school came into ours with a knife looking for a student in one of the classes but the police came and handled the situation accordingly and our teachers were well prepared questions concerning criminal justice and safety and practiced lockdowns on a regular basis. Later we all found out this situation happened because of activity outside of school. My personal experiences in high school I never had a physical altercation with anyone but in grades 10 and 11 a lot of students would make organized fights after school and a big crowd would join. I think this relates to the previous question on men being more violent, because teenagers have no other way to assert their manliness to friends and girls other then to fight and beat someone up. I think the most dangerous places in our rural communities is back alleys at night time walking home from drinking at a friends or at a bar. You make yourself an easy target being drunk and that’s when criminals take the chance to mug you. By being at school it’s really hard to make yourself a big target with teaching staff all around you. To sum everything up I do not agree that schools are the most dangerous place for young people. In some instanced even your own home could be the most dangerous place to be and school could be like an escape for some students. questions concerning criminal justice and safety Reference Page The Canadian Encyclopedia, Criminal Law, http://www.thecanadianencyclopedia.com/articles/criminal-law, para. 1. Michael Moore, Bowling For Columbine, 2002.  Paul H. Robinson, John M. Darley, Does Criminal Law Deter? A Behavioural Science Investigation, Oxford Journal of Legal studies, volume 24, No. 2 (2004), pp. 173-205. School Safety, http://www.ncpc.org/topics/school-safety. Women and The Criminal Justice System, http://www.statcan.gc.ca/pub/89-503-x/2010001/article/11416-eng.htm.

Strategic Human Resource Management Practices - 2365 Words

STRATEGIC HUMAN RESOURCE MANAGEMENT: Strategic human resource is a technique allowing business to manage their human resources by giving entity the imperative structure to achieve future objectives and aims. Focusing on continual issues relating to employees, values, structure, culture, commitment and maintaining resources in an organisation. It is also defined as the direction and scope of organization over longer term, which ideally matches its resources to its changing environment, and in particular, to its markets, customers and clients to meet stakeholder expectations. (Johnson, G and Scholes, K 1993. Exploring corporate strategy, prentice hall, Hemel Hempstead. BOOK, Human resource management practice). HUMAN RESOURCE MANAGEMENT:†¦show more content†¦The HR strategy forms the basis for it. (http://www.ukessays.com/essays/business/hrm-at-tescos-tarmac-and-scottish-power-business-essay.php) IMPORTANCE OF HRM IN SCOTTISH POWER: For Scottish power employees are the assets or most important resource. The purpose of HRM in Scottish power is to handle affairs or issues regarding employees as it known to be driven by technical competence of individuals. It involves placing of individuals on unengaged positions, for recruiting and selection process taking into account appropriate qualification and skills. The organisation is putting emphases on fair and unbiased treatment among all the individuals of the company regardless of gender, age, race and disability. (http://www.ukessays.com/essays/business/hrm-at-tescos-tarmac-and-scottish-power-business-essay.php) B. (AC1.3) ANALYSIS OF THE FRAMEWORK OF STRATEGIC HRM OF TARMAC: Tarmac is UK based company that came into operational existence in 1903 and deals in supplying of building material and aggregates to the building industry. They have been dealing in building projects and construction of roads. They have TARMAC UK and TARMAC international. Tarmac UK is looking after two different businesses i.e. Tarmac LTD extracts key building aggregate and Tarmac building products LTD converting raw materials